Results of previous studies

First Study

A pilot pharmacogenomic study of the influence of cytotoxic target and metabolising gene polymorphisms on chemotherapy toxicity and outcome in osteosarcoma

Research category: Biological

Dr Rachael Windsor (Principal Investigator)

Funded: 2007
Amount: £71,956

Second Study

TARGETING FGF RECEPTOR SIGNALLING FOR THE TREATMENT OF OSTEOSARCOMA

Takeshi Kashima, Daniel Weekes, Agi Grigoriadis

Research category: Biological

Date funded: 2007
Amount: £59,440

This study aimed to gain further evidence and expand knowledge on the potential role of Fibroblast Growth Factor (FGF) and FGF Receptor (FGFR) signalling in the pathogenesis of osteosarcoma, its possible role in metastasis, and confirm this pathway for translation as a potential novel therapeutic target.

Third Study

Ewing's sarcoma - pre-clinical in vivo model

Professor Josef Vormoor

Research category: Translational

Date funded: 2008
Amount: £31,772

The University of Newcastle's acquisition of small animal Magnetic resonance Imaging (MRI), Computerised Tomography (CT) and Positron Emission Tomography (PET) equipment has enabled this research group to propose and carry out pre-clinical research to examine Ewing's sarcomas and the effects of novel drug treatments in animals.

Fourth Study

Investigating the combination of fenretinide and TRAIL receptor agonist in Ewing's Sarcoma Family of Tumours.

Dr D White, Professor SA Burchill.